Great Western Way is closed in both directions due to a serious crash.
Two vehicles collided outside TK Maxx, on the Cockleberry Roundabout in Swindon town centre, at around 12.15am this morning, Tuesday 12 July.
Swift Medics, alongside the ambulance service are on scene delivering critical care.
Dorset and Wiltshire Fire and Rescue Service are also in attendance, and have extracted one or more casualties by removing the roof of one of the vehicles.
Access to the Cockleberry Roundabout is blocked by Wiltshire Police at Transfer Bridges, Whitehouse Road (rear-side of Swindon College) and Station Road.